At a time when our world is facing unprecedented challenges, from climate change to political polarization to a global pandemic, entrepreneurs and nongovernmental organization (NGO) leaders cannot afford to operate in silos. Entrepreneurs possess resourcefulness, creativity, and initiative; heads of nonprofit organizations are equipped with depth of knowledge, purpose, and the patient determination that comes with that purpose. Together, these partners can turbocharge impact if they properly calibrate their respective contributions to create new social enterprises.